A New Stilbene from the root of cassia sieberiana D.C. (Fabaceae)

Research output: Research - peer-reviewArticle

Abstract

A new stilbene (1) was isolated from the root of Cassia sieberiana D. C. together with thirteen known compounds, one stilbene (2), three flavonoids (3-5), six anthraquinones (6-11), two triterpenes (12-13), and phytosterol (14). Their structures were identified using spectroscopic techniques and by comparison of the spectral data with those previously reported in the literature. Compounds 10-13 were isolated from C. sieberiana for the first time. Compounds 1, 2 and 3 exhibited significant inhibitory activity on 15-lipoxygenase with IC50 values of 2.62, 1.27 and 0.98 ìM, respectively. Compounds 2 and 3 showed acetylcholinesterase inhibitory activity with IC50 values of 10.57 and 2.89 ìM, respectively.

LanguageEnglish
Pages1095-1098
Number of pages4
JournalNatural Product Communications
Volume12
Issue number7
StatePublished - 2017

Fingerprint

Cassia
stilbenes
Fabaceae
Stilbenes
anthraquinones
phytosterols
acetylcholinesterase
lipoxygenase
triterpenoids
spectral analysis
flavonoids
methodology
Arachidonate 15-Lipoxygenase
Phytosterols
Anthraquinones
Triterpenes
Acetylcholinesterase
Flavonoids

Keywords

  • 15-Lipoxygenase
  • Acetylcholinesterase
  • Anthraquinone
  • Cassia sieberiana
  • Flavonoids
  • Stilbene

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

A New Stilbene from the root of cassia sieberiana D.C. (Fabaceae). / Jibril, Saidu; Sirat, Hasnah Mohd; Basar, Norazah.

In: Natural Product Communications, Vol. 12, No. 7, 2017, p. 1095-1098.

Research output: Research - peer-reviewArticle

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