Photo of Syazwani Itri Amran

Syazwani Itri Amran

Senior Lecturer

  • 31 Citations
  • 2 h-Index
20112013

Personal profile

URL

http://fbme.utm.my/

Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

1-Phosphatidylinositol 4-Kinase Medicine & Life Sciences
Protein Isoforms Medicine & Life Sciences
Amino Acids Medicine & Life Sciences
In Vitro Techniques Medicine & Life Sciences
Prodrugs Medicine & Life Sciences
Mutagenesis Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Enzymes Medicine & Life Sciences

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Research Output 2011 2013

  • 31 Citations
  • 2 h-Index
  • 3 Article
2 Citations

Potent Inhibitors of Phosphatidylinositol3 (PI3) Kinase that have Antiproliferative Activity Only When Delivered as Prodrug Forms

O'Brien, N. J., Amran, S., Medan, J., Cleary, B., Deady, L. W., Jennings, I. G., Thompson, P. E. & Abbott, B. M. Jun 2013 In : ChemMedChem. 8, 6, p. 914-918 5 p.

Research output: Contribution to journalArticle

Prodrugs
Phosphotransferases
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
MCF-7 Cells
Cell Proliferation
12 Citations

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis

Zheng, Z., Amran, S. I., Zhu, J., Schmidt-Kittler, O., Kinzler, K. W., Vogelstein, B., Shepherd, P. R., Thompson, P. E. & Jennings, I. G. 15 Jun 2012 In : Biochemical Journal. 444, 3, p. 529-535 7 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Mutagenesis
Protein Isoforms
Amino Acids
In Vitro Techniques
17 Citations

Isoform-selective inhibition of phosphoinositide 3-kinase: Identification of a New Region of nonconserved amino acids critical for p110α inhibition

Zheng, Z., Amran, S. I., Thompson, P. E. & Jennings, I. G. Oct 2011 In : Molecular Pharmacology. 80, 4, p. 657-664 8 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Protein Isoforms
Amino Acids
Phosphatidylinositols
X Ray Crystallography